Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23561
Title: Analgesic activity of new synthetic thiazolidine-4-ones derivatives
Authors: Sushma, M
Sudha, S
Shivamurthy, N
Venkataraman, BV
Keywords: Thiazolidine-4-ones;Tail flick test;Tail immersion test;Acetic acid writhing test;Analgesic activity;Structure activity relationship;Chlorothiazolidine-4-ones;Methoxythiazolidine-4-ones;Hydroxythiazolidine-4-ones
Issue Date: Aug-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl7 A61P
Abstract: Ten new synthetic thiazolidine-4-ones derivatives (5 chlorothiazolidine-4-ones, 3 methoxythiazolidine-4-ones and 2 hydoxythiazolidine-4-ones) having different substituents at R1, R2 and R3 were evaluated for their analgesic activity using different animal models and their structure activity relationship was also elucidated. Chlorothiazolidine-4-ones and methoxythiazolidine-4-ones exhibited analgesic activity in tail flick test, tail immersion test and acetic acid writhing test. C-III (chloride substituents at R1 and R2) produced higher latencies than any other compounds in tail flick test and C-I (no substituents at R1 and R2) was not effective in acetic acid writhing test. Hydroxythiazolidine-4-ones did not show analgesic activity in any of the animal models used. In conclusion, the character of substituents at R3 of thiazolidine moiety position may have an effect on the analgesic activity of thiazolidine-4-ones and either chloride or methoxy substitution may be necessary to produce analgesic activity. Two chloride substituents in a compound may increase the central analgesic activity of the compound.
Page(s): 812-815
URI: http://hdl.handle.net/123456789/23561
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(08) [August 2004]

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