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dc.contributor.authorAbdulrahman, F-
dc.contributor.authorInyang, I S-
dc.contributor.authorAbbah, J-
dc.contributor.authorBinda, L-
dc.contributor.authorAmos, S-
dc.contributor.authorGamaniel, K-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractEffect of the aqueous leaf extract of I.gabonensis on the gastrointestinal tract was investigated on isolated rabbit jejunum, guinea pig ileum, gastrointestinal motility, castor oil-induced diarrhoea in mice and castor oil-induced fluid accumulation in rats. The results showed that the extract exhibited a concentration-dependent relaxation of spontaneous pendular movement of isolated rabbit jejunum and guinea pig ileum, and attenuated both acetylcholine-induced contraction of rabbit jejunum and histamine-induced contraction of guinea pig ileum. The extract (100, 200 and 400 mg/kg) also caused a significant dose-dependent decrease of gastrointestinal motility in mice (40.12, 39.45 and 37.45%), intestinal fluid accumulation in rats (71.43, 81.63 and 83.27%), and remarkably protected mice against castor oil-induced diarrhoea [58.33, 75 and 91.67% (Di Carlo score)] respectively. Preliminary phytochemical screening of the aqueous leaf extract of I.gabonensis revealed the presence of saponins, tannins, phenols and phlobatanins.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. Cl.7, A 61 Pen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.42(08) [August 2004]en_US
dc.subjectGastrointestinal tracten_US
dc.subjectIrvingia gabonensisen_US
dc.titleEffect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodentsen_US
Appears in Collections:IJEB Vol.42(08) [August 2004]

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