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Title: Effect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodents
Authors: Abdulrahman, F
Inyang, I S
Abbah, J
Binda, L
Amos, S
Gamaniel, K
Keywords: Diarrhoea;Gastrointestinal tract;Irvingia gabonensis
Issue Date: Aug-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.7, A 61 P
Abstract: Effect of the aqueous leaf extract of I.gabonensis on the gastrointestinal tract was investigated on isolated rabbit jejunum, guinea pig ileum, gastrointestinal motility, castor oil-induced diarrhoea in mice and castor oil-induced fluid accumulation in rats. The results showed that the extract exhibited a concentration-dependent relaxation of spontaneous pendular movement of isolated rabbit jejunum and guinea pig ileum, and attenuated both acetylcholine-induced contraction of rabbit jejunum and histamine-induced contraction of guinea pig ileum. The extract (100, 200 and 400 mg/kg) also caused a significant dose-dependent decrease of gastrointestinal motility in mice (40.12, 39.45 and 37.45%), intestinal fluid accumulation in rats (71.43, 81.63 and 83.27%), and remarkably protected mice against castor oil-induced diarrhoea [58.33, 75 and 91.67% (Di Carlo score)] respectively. Preliminary phytochemical screening of the aqueous leaf extract of I.gabonensis revealed the presence of saponins, tannins, phenols and phlobatanins.
Page(s): 787-791
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(08) [August 2004]

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