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dc.contributor.authorChandra, Amar K-
dc.contributor.authorGhosh, Dishari-
dc.contributor.authorMukhopadhyay, Sanjukta-
dc.contributor.authorTripathy, Smritiratan-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractYoung shoots or sprouts of common bamboos are used as food in third world countries. Evidences suggest the presence of cyanogenic glucoside like anti-thyroidal substance in bamboo shoots (BS) but effect of prolonged BS consumption on thyroid status under conditions of varying iodine nutriture remains unexplored. The study was undertaken to evaluate goitrogenic content, in vitro anti thyroid peroxidase (TPO) activity and in vivo anti thyroid potential of BS with and without extraiodide. Fresh BS contains high cyanogenic glucoside (551 mg/kg), followed by thiocyanate (24mg/kg) and glucosinolate (9.57mg/kg). In vitro inhibition in TPO activity was found with raw, raw boiled and cooked extracts. Inhibition constant (IC50) and PTU equivalence of fresh BS were 27.5±0.77 pg and 3.27 respectively. Extra iodide in the incubation media reduced TPO inhibition induced by BS but could not cancel it. Thyroid weight, TPO activity and total serum thyroid hormone levels of BS fed animals for 45 and 90 days respectively were determined and compared with controls. Significant increase in thyroid weight as well as higher excretion of thiocyanate and iodine along with marked decrease in thyroid peroxidase activity, T4 and T3 levels were observed in BS fed group. Chronic BS consumption gradually developed a state of hypothyroidism. Extra iodide had reduced the anti-thyroidal effect of BS to an extent but could not cancel it because of excessive cyanogenic glucoside, glucosinolate and thiocyanate present in it.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. Cl7. A61K35en_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.42(08) [August 2004]en_US
dc.subjectBamboo shooten_US
dc.subjectCyanogenic glucosidesen_US
dc.subjectThyroid peroxidaseen_US
dc.subjectThyroid hormonesen_US
dc.titleEffect of bamboo shoot, Bambusa arundinacea (Retz.) Willd. on thyroid status under conditions of varying iodine intake in ratsen_US
Appears in Collections:IJEB Vol.42(08) [August 2004]

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