Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23538
Title: Effect of dietary n-3 and n-6 fatty acids on tobramycin induced nephrotoxicity
Authors: Sheema
Kaleem, M
Bano, Bilqees
Keywords: Aminoglycosides;Tobramycin;Nebramycin;Nephrotoxicity;n-3 fatty acids;Fish oil;n-6 fatty acids;Olive oil;Urea;Creatinine
Issue Date: Jul-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl7 A61K
Abstract: Post fish oil(n-3 fatty acids) treatment (5mg/kg/day for 12 days) was effective in bringing the reversal of tobramycin (160mg/kg/day,ip for 12 days) induced nephrotoxicity in albino rats as was evident by normal urea, creatinine, cholesterol and inorganic phosphate levels in the serum of the treatment group compared with group receiving tobramycin only. The return of normal levels of alkaline and acid phosphatase in kidney homogenates of post fish oil treatment group also indicated the beneficial effect of dietary n-3 fatty acids(fish oil) more than n-6 fatty acids(olive oil).The results suggest that oral supplements of dietary n-3 fatty acids (fish oil) for nearly two weeks after tobramycin exposure is more beneficial than n-6 fatty acids (olive oil) as it results in reversal of nephrotoxicity induced by tobramycin.
Page(s): 691-697
URI: http://hdl.handle.net/123456789/23538
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(07) [July 2004]

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