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dc.contributor.authorSingh, Vijay Pal-
dc.contributor.authorPatil, Chandrashekhar S-
dc.contributor.authorKulkarni, Shrinivas K-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractLeukotrienes play a part in inflammatory response. The unique role of the enzyme 5- lipoxygenase (5-LOX) in the production of leukotrienes makes it a likely therapeutic target for inflammatory conditions like asthma, rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD). The aim of the present study was to evaluate the effect of zileuton, an orally active selective 5-LOX inhibitor against the events associated with dextran sodium sulphate- induced colitis in a rat model of IBD.The animals were administered simultaneously zileuton (100mg/kg) or sulphasalazine (100mg/kg) orally for 7 days. On day eight, rats were sacrificed, and distal colon isolated to determine myeloperoxidae activity, in vivo superoxide dismutase activity, prostaglandin E2 levels and histological examination. Both zileuton and sulphasalazine significantly prevented the development of inflammatory events associated with colitis. The effect of zileuton was more pronounced towards reducing myeloperoxidase activity and increasing PGE2 levels in distal colon. The results show that chemotactic leukotrienes are responsible for inflammatory surge in damaged colon and, zileuton, significantly improved healing by inhibition of neutrophil recruitment and indirectly through increase in prostaglandins at the site of inflammation. It is suggested that inhibitors of 5-LOX enzyme may have useful therapeutic role in the treatment of chronic intestinal inflammation.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.42(07) [July 2004]en_US
dc.subjectInflammatory bowel diseaseen_US
dc.subject5- Lipoxygenase: 5-LOXen_US
dc.titleEffect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in ratsen_US
Appears in Collections:IJEB Vol.42(07) [July 2004]

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