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Title: Antiulcerogenic activity of Satavari mandur-An Ayurvedic herbo-mineral preparation
Authors: Datta, G K
Sairam, K
Priyambadi, S
Debnath, P K
Goel, R K
Issue Date: Oct-2002
Publisher: NISCAIR-CSIR, India
Abstract: Satavari mandur (SM) is a herbo-mineral preparation containing Asparagus racenmosus, which finds mention in ancient Indian texts for treatment of gastric ulcers. The ulcer protective effect of SM, 125-500 mg/kg given orally, twice daily for three, five and seven days, was studied on cold restraint stress-induced gastric ulcer in rats. The effective regimen was found to be 250 mg/kg given for five days and hence was used for further experiments. SM showed significant protection against acute gastric ulcers induced by pyloric ligation but was ineffective against aspirin- and ethanol-induced ulcers. Further, gastric juice studies showed that, SM significantly increased the mucosal defensive factors like mucus secretion, but had little or no effect on offensive factors like acid and pepsin secretion.
Page(s): 1173-1177
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.40(10) [October 2002]

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