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Title: Effect of poly herbal formulation, EuMil, on neurochemical perturbations induced by chronic stress
Authors: Bhattacharya, A
Muruganandam, A V
Kumar, Vikas
Bhattacharya, S K
Issue Date: Oct-2002
Publisher: NISCAIR-CSIR, India
Abstract: EuMil, a polyherbal formulation consisting of standardised extracts of Withania somnifera (L) Dunal, Ocimum sanctum L., Asparagus racemosus Wild and Emblica officinalis Gaertn., is used as an anti-stress agent to attenuate the various aspects of stress related disorders. In the present study, the neurochemical mechanisms underlying the anti-stress activity of EuMil were evaluated by measuring the rat brain monoamine neurotransmitter levels and tribulin activity. Chronic electroshock stress (14 days) significantly decreased the nor-adrenaline (NA) and dopamine (DA) levels in frontal cortex, ponsmedulla, hypothalamus, hippocampus and striatal, hypothalamal region, respectively, and increased the 5- hydroxytryptamine (5HT) level in frontal cortex, pons medulla, hypothalamus and hippocampus. Chronic stress, also increased the rat brain tribulin activity. EuMil (100 mg/kg, p.o., 14 days) treatment normalized the perturbed regional NA, DA, 5HT concentrations, induced by chronic stress. EuMil also significantly attenuated the stress-induced increase in the rat brain tribulin activity. The amelioration of chronic stress-induced neurochemical perturbations by EuMil explains the neurochemical mechanisms underlying the observed putative anti-stress activity of the product.
Page(s): 1161-1163
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.40(10) [October 2002]

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