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Title: Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats
Authors: Muruganandam, A V
Kumar, Vikas
Bhattacharya, S K
Issue Date: Oct-2002
Publisher: NISCAIR-CSIR, India
Abstract: EuMil, is a herbal formulation comprising the standardised extracts of Withania somnifera (L) Dunal. Ocimum sanctum L., Asparagus racemosus Wild and Emblica officinalis Gaertn ., all of which are classified in Ayurveda as rasayanas to promote physical and mental health improve defense mechanisms of the body and enhance longevity. These attributes are similar to the modern concept of adaptogenic agents, which are, known to afford protection to the human physiological system against diverse stressors. The present study was undertaken to investigate the adaptogenic and antistress activity of EuMil against chronic unpredictable, but mild, footshock stress-induced perturbations in behaviour (depression), glucose metabolism, suppressed male sexual behavior, immunosuppression and cognitive dysfunction in CF strain albino rats. Panex ginseng (PG) was used for comparison. Gastric ulceration, plasma corticosterone levels, serum lipid, hepatic and renal functions were used as the stress indices. These effects were attenuated by EuMil (dose 100 mg/kg. p.o.) and PG (100 mg/kg. p.o.), administered once daily over a period of 14 days, the period of stress induction period. Further, chronic stress also induced glucose intolerance, suppressed male sexual behavior, induced behavioural despair and cognitive dysfunction and immunosuppression. All these chronic stress-induced perturbations were attenuated, in a dose dependent manner by EuMiI and PG. Thus, the results indicate that EuMil has significant adaptogenic and anti-stress, activity, qualitatively comparable to PG, against a variety of behavioural , ┬ábiochemical and physiological perturbations, induced by unpredictable stress, which has been proposed to be a better indicator of clinical stress than acute stress. The likely contribution of the individual constituents of EuMil in the observed adaptogenic action of the polyherbal formulation, has been discussed.
Page(s): 1151-1160
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.40(10) [October 2002]

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