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Title: Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection
Authors: Goel, H C
Kumar, I Prem
Rana, S V S
Issue Date: Jun-2002
Publisher: NISCAIR-CSIR, India
Abstract: Aqueous extract of T. cordifolia inhibited Fenton (FeSO4) reaction and radiation mediated 2-deoxyribose degradation in a dose dependent fashion with an IC50 value of 700µg/ml for both Fenton and radiation mediated 2-DR degradation. Similarly, it showed a moderate but dose dependent inhibition of chemically generated superoxide anion at 500 µg/ml concentration and above with an IC50 value of 2000 µg/ml. Aqueous extract inhibited the formation of Fe2+-bipiridyl complex and formation of comet tail by chelating Fe2+ ions in a dose dependent manner with an IC50 value of 150 µg/ml for Fe2+  -bipirydyl formation and maximally 200 µg/ml for comet tail formation, respectively. The extract inhibited ferrous sulphate mediated lipid peroxidation in a dose-dependent manner with an IC50 value of 1300 µg/ml and maximally (70%) at 2000  µg/ml. The results reveal that the direct and indirect antioxidant actions of T. cordifalia probably act in corroboration to manifest the overall radioprotective effects.
Page(s): 727-734
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.40(06) [June 2002]

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