Please use this identifier to cite or link to this item:
|Title:||Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum & Thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential|
|Authors:||Raphael, K Regi|
Sabu, M C
|Abstract:||Methanolic extract of P. amarus was found to have potential anti-oxidant activity as it could inhibit lipid peroxidation, and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 104µg/ml and the concentrations needed to scavenge hydroxyl and superoxide radicals were 117 and 19 µg/ml respectively. The extract was found to reduce the blood sugar in alloxan diabetic rats at 4th hr by 6% at a dose level of 200 mg/kg body wt and 18.7% at a concentration of 1000 mg/kg body wt. Continued administration of the extract for 15 days produced significant (P < 0.001) reduction in blood sugar . On 18th day after alloxan administration values were almost similar to normal in the group taking 1000 mg/kg body wt.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.40(08) [August 2002]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.