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Title: Overexpression of c-erbB-2 oncoprotein and associated pathobiological factors in invasive primary breast cancer
Authors: Ray, Amitabha
Sharma, Bhuvnesh Kumar
Kaur, Sudershan
Sharma, Shashi
Sharma, Joginder Kumar
Keywords: Breast cancer;c-erbB-2;EGF-R menopausal status;Oncoprotein
Issue Date: Mar-2004
Publisher: NISCAIR-CSIR, India
Abstract: Breast cancer tissues from 271 cases were analyzed immunologically for c-erbB-2 oncoprotein (HER-2/neu), epidermal growth factor receptor (EGF-R) and estrogen receptor (ER). Overexpression of both c-erbB-2 oncoprotein and EGF-R showed an inverse association with ER and a direct association with metastatic involvement of lymph node and high histological grade. The frequency of c-erbB-2 and EGF-R overexpression was significantly higher among postmenopausal cases in comparison with premenopausal cases. Further, only in postmenopausal patients, c-erbB-2 oncoprotein (2=6.4, P < 0.05) and EGF-R (2=6.4, p<0.05) as well as their concomitant expression (2= 11.5, p<0.01) revealed a statistically significant association with ER.
Page(s): 253-258
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(03) [March 2004]

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