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Title: Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Authors: Pungle, Pratibha
Banavalikar, M
Suthar, A
Biyani, M
Mengi, S
Keywords: Anti -anaphylactic activity;Boswellic acid; Boswellia serrata;Mast cell stabilizing activity
Issue Date: Dec-2003
Publisher: NISCAIR-CSIR, India
Abstract: Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto β- boswellic acid (KBA), acetyl β- boswellic acid and β- boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20,40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependent manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (SO mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising anti anaphylactic and mast cell stabilizing activity of the extract.
Page(s): 1460-1462
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(12) [December 2003]

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