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Title: Nuclear transcription factor NF-kappa B: Role in biology and medicine
Authors: Aggarwal, Bharat B
Takada, Yasunari
Shishodia, Shishir
Gutierrez, Angelica M
Oommen, Oommen V
Ichikawa, Haruyo
Baba, Yuh
Kumar, Ashok
Keywords: NF-ҡB;Tumorigenesis;Inflammation;Immunity;Therapy
Issue Date: Apr-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.7 A61 K 48/00
Abstract: The inducible transcription factor nuclear factor-kappa B (NF-ҡB) plays a central role in regulation of many immune, inflammatory and carcinogenic responses. While normal activation of NF-ҡB is required for cell survival and immunity, aberrant regulation of NF-ҡB leads to development of many pathological states especially those involved in acute inflammation. Recent advances in our knowledge of the signaling mechanisms those control the activation of NF-ҡB highlights the intriguing aspect of NF-ҡB regulation , namely the ability of many different signal transduction pathways originating from a wide variety of inducing mechanisms to converge on a single target, the NF-ҡB/IҡB complex. In this review we summarize our current understanding of the NF-ҡB signaling pathways, their role in various cellular responses and the potential of using NF-ҡB as a therapeutic target in modern medicine.
Page(s): 341-353
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(04) [April 2004]

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