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Title: α-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats
Authors: Kumar, M Satish
Prashanth, K V Harish
Keywords: Lipoic acid (α);Colonic contractility;Intestinal transit;STZ-diatetes;Rat
Issue Date: Mar-2004
Publisher: NISCAIR-CSIR, India
Abstract: α-Lipoic acid treatment (100 mg/kg/day for 2 weeks after 6 weeks of untreated diabetes) of streptozotocin diabetic rats partially but significantly reversed both reduced contractile response of distal colon to acetylcholine and delayed transit of charcoal meal in small intestine compared to diabetic control. These effects of α-Lipoic acid were associated with complete reversal of diabetes induced increased plasma lipid peroxidation level. α-Lipoic acid had no effect on any of the parameters measured in non-diabetic rats. These findings demonstrate contribution of oxidative stress in the development of physiological changes of gut in diabetes.
Page(s): 279-282
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(03) [March 2004]

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