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dc.contributor.authorPeer, M A-
dc.contributor.authorShah, N A-
dc.contributor.authorKhan, K A-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractThis paper gives an over view of the use of cellular automata (CA) model of drug therapy for HIV infection. Non-uniform CA is employed to simulate drug treatment of HIV infection, where each computational domain may contain different CA rules, in contrast to normal uniform CA models. Ordinary (or partial) differential equation models are insufficient to describe the two extreme time scales involved in HIV infection (days and decades), as well as the implicit spatial heterogeneity. Zorzenon and Coutinho [Phy Rev Lett, 16 (2001) 1] reported a cellular automata approach to simulate three-phase patterns of human immunodeficiency virus (HIV) infection consisting of primary response, clinical latency and onset of acquired immunodeficiency syndrome (AIDS). But here we present a related model, based on non-uniform CA to study the dynamics of drug therapy of HIV infection. The main aim in this model is to simulate the four phases (acute, chronic, drug treatment responds and onset of AIDS). The results shown here indicate that both simulations (with and without treatments) evolve to the relatively same steady state (characteristics of Wolfram's class II behavior). Different kinds of drug therapies can also be simulated in this model, which can be found useful for developing a proper drug therapy .en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.42(02) [February 2004]en_US
dc.subjectCellular automataen_US
dc.subjectDrug therapyen_US
dc.titleCellular automata and its advances to drug therapy for HIV infectionen_US
Appears in Collections:IJEB Vol.42(02) [February 2004]

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