Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23347
Title: Cellular automata and its advances to drug therapy for HIV infection
Authors: Peer, M A
Shah, N A
Khan, K A
Keywords: Cellular automata;Drug therapy;HIV-AIDS
Issue Date: Feb-2004
Publisher: NISCAIR-CSIR, India
Abstract: This paper gives an over view of the use of cellular automata (CA) model of drug therapy for HIV infection. Non-uniform CA is employed to simulate drug treatment of HIV infection, where each computational domain may contain different CA rules, in contrast to normal uniform CA models. Ordinary (or partial) differential equation models are insufficient to describe the two extreme time scales involved in HIV infection (days and decades), as well as the implicit spatial heterogeneity. Zorzenon and Coutinho [Phy Rev Lett, 16 (2001) 1] reported a cellular automata approach to simulate three-phase patterns of human immunodeficiency virus (HIV) infection consisting of primary response, clinical latency and onset of acquired immunodeficiency syndrome (AIDS). But here we present a related model, based on non-uniform CA to study the dynamics of drug therapy of HIV infection. The main aim in this model is to simulate the four phases (acute, chronic, drug treatment responds and onset of AIDS). The results shown here indicate that both simulations (with and without treatments) evolve to the relatively same steady state (characteristics of Wolfram's class II behavior). Different kinds of drug therapies can also be simulated in this model, which can be found useful for developing a proper drug therapy .
Page(s): 131-137
URI: http://hdl.handle.net/123456789/23347
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(02) [February 2004]

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