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Title: Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice
Authors: Singh, Vijay Pal
Patil, Chandrashekhar S
Kumar, Manish
Kulkarni, Shrinivas K
Keywords: Hypothermia;Lipopolysaccahride;Lcukotriene B4;5-Lipoxygcnase;5-LOX;Prostaglandin E2
Issue Date: Dec-2005
Publisher: NISCAIR-CSIR, India
Abstract: Bacterial endotoxin produces sepsis associated with alterations in body temperature (fever or hypothermia). The intraperitoneal administration of bacterial endotoxin, lipopolysaccharide (LPS; 50 μg/mouse) led to a decrease in colonic temperature starting 1 hr after the injection. The hypothermic effect was accompanied by a significant increase in hypothalamic leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) levels. 5-lipoxygenase inhibitor, zileuton (200 and 400 Mg/kg. po) administered 30 min before LPS challenge significantly prevented hypothermia. However, non-selective cyclooxygenase inhibitor, indomethacin (10, 20 mg/kg, po) did not reverse the hypothermic response. Further, pretreatment of mice with zileuton prevented LPS-stimulated increase in hypothalamic LTB4 levels and caused a relatively small increase in PGEz levels. Indomethacin had no effect on LTB4 levels but it reduced PGE2 levels. These results suggest a possible involvement of leukotrienes in LPS-induced hypothermia and the potential protective role of 5-lipoxygenase inhibitors in endotoxemia.
Page(s): 1150-1155
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(12) [December 2005]

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