Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23219
Title: Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors
Authors: Goel, R K
Sairam, K
Dorababu, M
Prabha, T
Rao, Ch V
Keywords: Antioxidants;Eugenol;Gastric ulcer protection and healing;Mucosal offensive and defensive factors;Ocimum sanctum
Issue Date: Aug-2005
Publisher: NISCAIR-CSIR, India
Abstract: The standardized methanolic extract of leaves of O. sanctum (OSE; eugenol content 5%) given in doses of 50-200 mg/kg. orally. twice daily for five days showed dose-dependent nicer protective effect against cold restraint stress induced gastric ulcers. Optimal effective dose (100 mg/kg) of OSE showed significant ulcer protection against ethanol and pyloric ligation-induced gastric ulcers, but was ineffective against aspirin-induced ulcers. OSE significantly healed ulcers induced by 50% acetic acid after 5 and 10 days treatment. OSE (100mg/kg) significantly inhibited the offensive acid-pepsin secretion and lipid peroxidation and increased the gastric defensive factors like mucin secretion, cellular mucus, and life span of mucosal cells and had antioxidant effect, but did not induce mucosal cell proliferation. The results indicate that the ulcer protective and healing effects of OSE may be due to its effects both on offensive and defensive mucosal factors.
Page(s): 715-721
URI: http://hdl.handle.net/123456789/23219
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(08) [August 2005]

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