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Title: Effect of vitamin A on lens regeneration in pigs
Authors: Jangir, O P
Modi, Deepshikha
Sharma, Manshi
Keywords: Lens regeneration;Pigs;Vitamin A
Issue Date: Aug-2005
Publisher: NISCAIR-CSIR, India
Abstract: Intraperitoneal injections of vitamin A (0.5 ml of 1500 IU/ml) to lentectomized pigs on alternate days up to 60th day after lentectomy induced lens regeneration in not only 10 days old young ones but also in 40 and 100 days old pigs. Lens regeneration did not occur even in a single case of control groups. In shape, size, transparency and histological features regenerated lenses were similar to normal intact lenses. The experimental model is the first to show that mitogenic and dedifferentiate activity of vitamin A can induce iris pigmented epithelial cells to trans-differentiate into new lens in pigs.
Page(s): 679-685
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(08) [August 2005]

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