Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/23180
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dc.contributor.authorKishore, Kamal-
dc.contributor.authorSingh, Manjeet-
dc.date.accessioned2013-11-08T12:11:37Z-
dc.date.available2013-11-08T12:11:37Z-
dc.date.issued2005-07-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/23180-
dc.description640-645en_US
dc.description.abstractTo investigate the effect of bacosides (alcoholic extract of brahmi) on scopolamine (3 mg kg-l , ip), sodium nitrite (75mg kg-l, ip) and BN52021 (15 mg kg-l, ip) induced experimental amnesia in mice, using Morris water maze test , all the agents were administered 30 min before the acquisition trials on each day and repeated for 4 consecutive days, and on 5th day during the retrieval trials. Bacosides on anterograde administration (before training) in mice, significantly decreased the escape latency time (ELT) during the acquisition trials for 4 consecutive days and increased the time spent (TS) in target quadrant during the retrieval trials on 5th day, and on retrograde administration (after training) bacosides were found not to affect TS significantly. Bacosides also significantly decreased the ELT and increased the TS in mice treated anterogradely with scopolamine and sodium nitrite. Bacosides did not exhibit any significant effect on TS of mice treated retrogradely with sodium nitrite. On the other hand, bacosides significantly increased the TS of mice treated retrogradely with BN52021. On the basis of the present results it can be concluded that bacosides facilitate anterograde memory and attenuate anterograde experimental amnesia induced by scopolamine and sodium nitrite possibly by improving acetylcholine level and hypoxic conditions, respectively. Beside this bacosides also reversed BN52021 induced retrograde amnesia, probably due to increase in platelet activating factor (PAF) synthesis by enhancing cerebral glutamate level.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.43(07) [July 2005]en_US
dc.subjectAmnesiaen_US
dc.subjectBrahmien_US
dc.subjectBacosidesen_US
dc.subjectMemoryen_US
dc.subjectMiceen_US
dc.subjectWater mazeen_US
dc.titleEffect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in miceen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.43(07) [July 2005]

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