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Title: Synthesis of some modified aurones as antileukemic and antibacterial agents
Authors: Deepthi, M
Harinadha, Babu V
Madhava, Reddy B
Keywords: Chalcones;Aurones;Oximes;Antileukemic activity;Antibacterial activity
Issue Date: Nov-2013
Publisher: NISCAIR-CSIR, India
Abstract: Cyclisation of 1-(2-hydroxyphenyl)-3-substituted phenylprop-2-en-1-ones 1a-h in pyridine with mercuric acetate gives different 2-benzylidene-1-benzofuran-3(2H)-ones 2a-h which on subsequent reaction with hydroxylamine hydrochloride affords 2-benzylidene-1-benzofuran-3(2H)-one oximes 3a-h. These oximes on reaction with benzoyl chloride / p-toluene sulphonyl chloride gives two series of compounds 4a-h and 5a-h. The compounds thus synthesized have been characterized by physical and spectral data. All the compounds have been screened for antileukemic and antibacterial activities.
Page(s): 1455-1461
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(11) [November 2013]

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