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Title: Synthesis and antibacterial/antitubercular activity evaluation of symmetrical trans-cyclohexane-1,4-diamine derivatives
Authors: Kumar, Nitin
Kapoor, Ekta
Singh, Ramandeep
Kidwai, Saqib
Kumbukgolla, Widuranga
Bhagat, Sunita
Rawat, Diwan S
Keywords: Bromhexine;trans-cyclohexane-1,4-diamine;Mycobacterium tuberculosis;Tuberculosis;Methicillin resistant Staphylococcus aureus (MRSA)
Issue Date: Nov-2013
Publisher: NISCAIR-CSIR, India
Abstract: A library of symmetrical trans-cyclohexane-1,4-diamine derivatives have been synthesized and evaluated for their activity against the M. tb H37Rv strain. Most of the synthesized compounds show moderate to weak activity against M. tb H37Rv strain. Out of twenty-seven compounds tested, four compounds having substitution at p-position on the aromatic ring exhibit activity with MIC99 value ranging from 12.5 - 25 µM. Compound 9u having i-propyl group substitution at p-position is found to be the most potent among all the tested compounds with MIC99 value of 12.5 µM against M. tb H37Rv strain. All these compounds have also been tested against Methicilin resistant Staphylococcus aureus (MRSA), and four of the compounds 9c, 9i, 9p and 9s possess good antibacterial activity with IC50 ranging from 128 mg/L – 256 mg/L.
Page(s): 1441-1450
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.52B(11) [November 2013]

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