Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23154
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dc.contributor.authorPradeep, K-
dc.contributor.authorMohan, C Victor Raj-
dc.contributor.authorAnand, K Gobi-
dc.contributor.authorKarthikeyan, S-
dc.date.accessioned2013-11-08T11:28:46Z-
dc.date.available2013-11-08T11:28:46Z-
dc.date.issued2005-06-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/23154-
dc.description526-530en_US
dc.description.abstractCCl4 alone treatment (0.1 ml of liquid paraffin/100g body weight, ip) for 7 days followed by 0.1 ml of CCl4 (in liquid parafiin/100g body weight, ip) from day 8 till day 14, caused a 16 fold increase in lipid peroxidation and a 50% reduction in catalase and glutathione reductase in liver tissue of rats accompanied by an increase in the activities of transaminases, alkaline phosphatase, lactate dehydrogenase and γ- glutamyl transpeptidase in serum as compared to liquid paraffin treated control. Pretreatment of ethanolic leaf extract of C. fistula (500mg/kg body weight/day for 7 days) followed by CCl4 treatment (0.1 ml/100g body weight from day 8 till day 14) completely reversed back lipid peroxidation and the activities of catalase and glutathione reductase in the liver tissue towards normalcy. This treatment also reversed the elevated levels of the enzymes in the serum. Ethanolic leaf extract alone treatment did not produce any change in all the parameters studied. The results suggest antioxidant and hepatoprotective properties of C. fistula during its pretreatment against CCl4 induced hepatotoxicity.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.43(06) [June 2005]en_US
dc.subjectAntioxidantsen_US
dc.subjectCassia fistula Len_US
dc.subjectCCl4en_US
dc.subjectHepatotoxicityen_US
dc.subjectHepatoprotectiveen_US
dc.titleEffect of pretreatment of Cassia fistula Linn. leaf extract against subacute CCl4 induced hepatotoxicity in ratsen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.43(06) [June 2005]

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