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dc.contributor.authorAugusti, K T-
dc.contributor.authorPrabha, S P-
dc.contributor.authorSmitha, K B-
dc.contributor.authorSudheesh, M-
dc.contributor.authorGeorge, Anu-
dc.contributor.authorJoseph, M C-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.description.abstractCarbon tetrachloride feeding (3.2g/kg/72hr) for one month increased significantly the serum and tissue lipid profile and deranged the enzyme levels viz; alkaline phosphatase, alanine transaminase, aspartate transaminase, glutathione reductase, HMGCoA reductase, catalase, gluc.6.PDH and malic enzyme in rats. Simultaneously the lipid peroxidation level in liver was also raised. On administration of garlic oil and its major nonpolar fraction (NPFGO) and a flavonoid isolated from the bark of Ficus bellgaiellsis Linn, viz; leucopelargonin derivative respectively to different groups(100mg/kg/day) the deleterious effects of CCl4 were significantly ameliorated. The liver damage by CCl4 was satisfactorily prevented by these samples as effectively as Vit. E (50 mg/kg/day). The results prove that important nutraceuticals (phytonutrients) like bioflavonoids and theols i.e. allylic sulphide rich fractions give protection from toxins like CCl4. The order of beneficial effects of the drugs are Leucopelargonin > NPFGO > Garlic oil and their effects are comparable to that of vitamin E used at a minimal dose.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.43(05) [May 2005]en_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectGarlic oilen_US
dc.subjectVitamin Een_US
dc.titleNutraceutical effects of garlic oil, its nonpolar fraction and a Ficus flavonoid as compared to vitamin E in CCl4 induced liver damage in ratsen_US
Appears in Collections:IJEB Vol.43(05) [May 2005]

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