Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23123
Title: Acute analgesic effect of loperamide as compared to morphine after intrathecal administration in rat
Authors: Ray, Subrata Basu
Verma, Dilip
Wadhwa, Shashi
Keywords: Analgesia;Calcium channel antagonist;Loperamide;Morphine;Mu-opioid receptor
Issue Date: May-2005
Publisher: NISCAIR-CSIR, India
Abstract: Loperamide, a mu opioid receptor agonist, which is commonly used as an antidiarrhoeal agent has been reported to possess analgesic activity after intrathecal administration. However, the exact analgesic profile, i.e., onset, duration and intensity of analgesia in -relation to morphine is not fully known. In the present study, the acute analgesic effect of loperamide (5 μg) was compared with that of morphine (5μg) and morphine + loperamide (5 μg of each) using the tail flick method after intrathecal administration. Naloxone (5 mg/kg) reversibility of the analgesic effect was also studied. The analgesic response of loperamide was significantly higher than morphine. Even after 22 hr, maximum possible effect was greater than 49%. Naloxone partially antagonized the analgesic effect of loperamide. This suggested that loperamide may be acting through blockade of Ca2+ channels besides activating mu opioid receptors. Loperamide may prove to be a better substitute for morphine as spinal analgesic.
Page(s): 425-429
URI: http://hdl.handle.net/123456789/23123
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(05) [May 2005]

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