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Title: Anti-lipidperoxidative role of exogenous dehydroepiendrosterone (DHEA) administration in normal ageing rat brain
Authors: Sinha, Nupur
Baquer, N Z
Sharma, Deepak
Keywords: Ageing;Anti-lipidperoxidation;Brain;Dehydroepiendrosterone;DHEA;Rat
Issue Date: May-2005
Publisher: NISCAIR-CSIR, India
Abstract: Effects of exogenous dehydroepiendrosterone (DHEA) administration on the levels of lipid proxidation products, malondialdyde (MDA)-a thiobarbuteric acid reactive substance (TBARS) and 4-hydroxy nonenal (4-HNE) in different brain regions viz. cerebral cortex, hippocampus cerebellum, and brain stem of 12 and 22 months old rats were studied. DHEA treatment significantly depressed TBARS and 4-HNE in all the brain regions studied, in both the age group rats. Interestingly, the magnitude of decrease was higher in the 22 months old rats than that in 12 months old rats. The results suggest that older the animal, better will be the response of exogenous DHEA administration against age- related peroxidative products.
Page(s): 420-424
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(05) [May 2005]

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