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Title: Antihepatotoxic effect of β-carotene on paracetamol induced hepatic damage in rats
Authors: Kumar, G
Banu, G Sharmila
Kannan, V
Pandian, M Rajasekara
Keywords: β-Carotene;Hepatic damage;Hepatoprotection;Paracetamol;Serum enzymes
Issue Date: Apr-2005
Publisher: NISCAIR-CSIR, India
IPC Code: Int Cl.7 A61P
Abstract: Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the β-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels, Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R), Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
Page(s): 351-355
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(04) [April 2005]

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