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Title: Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation
Authors: Singh, Vijay Pal
Patil, Chandrashekhar S
Kulkarni, Shrinivas K
Keywords: Gastric ulceration;NSAIDs;Licofelone;LTB4;LOX;Neutrophils
Issue Date: Mar-2005
Publisher: NISCAIR-CSIR, India
Abstract: The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase 1/2-5-lipoxygenase against indomethacin-induced gastric damage in rats and mice in order to assess the role of leukotrienes if any, in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal inflammation. Acute pretreatment with licofelone reversed the indomethacin-induced gastric ulceration, neutrophil adhesion in mesentery venules, neutrophil count in blood, lipid peroxides and vascularity in the stomachs of mice and rats. Further, chronic pretreatment of licofelone also prevented indomethacin-induced gastric morphological changes and cellular infiltration in mesentery venules. Moreover, acute admini stration of indomethacin elevated leukotriene B4 levels in gastric mucosa, which was reversed by pretreatment with licofelone The results suggest that licofelone offered gastroprotection against NSAIDs-induced gastropathy through its effect on leukotrienes and by inhibiting extravasation of neutrophils.
Page(s): 247-253
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(03) [March 2005]

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