Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/23007
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dc.contributor.authorMishra, Neerad C-
dc.contributor.authorKumar, Shailendra-
dc.date.accessioned2013-11-06T10:03:36Z-
dc.date.available2013-11-06T10:03:36Z-
dc.date.issued2005-01-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/23007-
dc.description25-34en_US
dc.description.abstractMitochondria play an important role in both the life and death of cells. The past 7-8 years have seen an intense surge in research devoted toward understanding the critical role of mitochondria in the regulation of cell death. Mitochondria have, next to their function in respiration, an important role in apoptotic signaling pathway. Apoptosis is a form of programmed cell death important in the development and tissue homeostasis of multicellular organisms. Apoptosis can be initiated by a wide array of stimuli, including multiple signaling pathways that, for the most part, converge at the mitochondria. Although classically considered the powerhouses of the cell, it is now understood that mitochondria are also "gatekeepers" that ultimately determine the fate of the cell. Malfunctioning at any level of the cell is eventually translated in the release of apoptogenic factors from the mitochondrial intermembrane space resulting in the organized demise of the cell. These mitochondrial factors may contribute to both caspase-dependent and caspase-independent processes in apoptotic cell death. In addition, several Bcl-2 family members and other upstream proteins also contribute to and regulate the apoptosis. In this review, we attempt to summarize our current view of the mechanism that leads to the influx and efflux of many proteins from/to mitochondria during apoptosis.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.43(01) [January 2005]en_US
dc.subjectc-Ablen_US
dc.subjectAIFen_US
dc.subjectApaf1en_US
dc.subjectApoptosisen_US
dc.subjectBcl-2en_US
dc.subjectCaspasesen_US
dc.subjectCell deathen_US
dc.subjectCytochrome cen_US
dc.subjectDIABLOen_US
dc.subjectJNKen_US
dc.subjectMitochondriaen_US
dc.subjectPKCδen_US
dc.subjectp53en_US
dc.subjectSmacen_US
dc.subjectTranslocationen_US
dc.subjectTR3en_US
dc.titleApoptosis: A mitochondrial perspective on cell deathen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.43(01) [January 2005]

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