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Title: Determination of felodipine in bulk drug and in tablets by high performance liquid chromatography
Authors: Basavaiah, K
Chandrashekar, U
Prameela, H C
Issue Date: Sep-2003
Publisher: NISCAIR-CSIR, India
Abstract: A rapid assay procedure based on high-performance liquid chromatography (HPLC) has been developed for the specific determination of antihypertensive drug felodipine in pharmaceutical formulations (tablets). The HPLC determination was carried out on a reversed-phase C18 (250×4.6 mm i.d) column using a mobile phase consisting of acetonitrile- 20 mM aqueous ammonium acetate buffer of pH 4.5 (80+20) at a flow rate of 1.0 mL min-1 with UV defection at 236 nm. Calibration graph was linear from 2.49 to 99.60 μg mL-1. The method has been validated according to current guidelines including the assay of pharmacopoeial standard tablets. Recoveries ranged from 97.80 to 102.10%. The excipient present in the tablets did not interfere in the method. The described HPLC method is comparable in terms of accuracy and precision with that of a reported method.
Page(s): 454-456
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.10(5) [September 2003]

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