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Title: Synthesis and β-adrenergic blocking activity of naphthyloxypropylamines
Authors: Vattipalli, Ramya
Shirodkar, Prabhakar Y
Somani, Rakesh R
Kadam, Vilasrao J
Keywords: Synthesis;β-adrenergic blockers;Aryloxypropanolamines
Issue Date: Oct-2008
Publisher: CSIR
Abstract: A series of 1-isopropylamino-3-(3'-substituted-2'-naphthyloxy)-2-propanols have been synthesized and their structures have been confirmed by spectral analysis. All the derivatives have shown β-adrenergic blocking effect when tested on perfused frog heart. Compound 4e exhibited 100% blockade of adrenaline response.
Page(s): 1587-1590
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(10) [October 2008]

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