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Title: p-Toluenesulfonic acid catalyzed rapid and efficient protocol for one-pot synthesis of α-amino nitriles
Authors: Reddy, Ch Sanjeeva
Raghu, M
Keywords: p-TsOH;α-amino nitriles;One-pot three-component condensation;Carbonyl compounds;Amines;Trimethylsilyl cyanide
Issue Date: Oct-2008
Publisher: CSIR
Abstract: A simple, rapid and efficient practical method for one-pot synthesis of α-amino nitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of p-toluenesulfonic acid (p-TsOH) as a catalyst at ambient temperature. Operational simplicity, economic consideration, high yield, short reaction time and low toxicity are the key features associated with this protocol.
Page(s): 1572-1577
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(10) [October 2008]

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