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|Title:||Synthesis of ()-7,8- and 5,6-dimethyl-2-(2-hydroxyisopropyl) tetralins|
|Authors:||Kadam, A J|
Desai, U V
Mane, R B
|Abstract:||7,8-Dimethyl-1-tetralone 4 on sodium borohydride reduction followed by Vilsmeier-Haack reaction furnishes 7,8-dimethyl-3,4-dihydro-2-naphthaldehyde 10. Reduction of 10 followed by oxidation with Jones reagent yields 7,8-dimethyl-1,2,3,4-tetrahydro-2-naphthoic acid 12 which on treatment with excess of methyllithium affords 7,8-dimethyl-2-(2 -hydroxyisopropyl) tetralin 2. 5,6-dimethyl-1-tetralone 5 is converted into the 5,6-dimethyl-2-(2-hydroxyisopropyl)tetralin 3 by following similar set of reactions as described above.|
|Appears in Collections:||IJC-B Vol.39B(10) [October 2000]|
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