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Title: Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents
Authors: Das, Nirupam
Verma, Abhilasha
Shrivastava, Prabhat K
Shrivastava, Sushant K
Keywords: Pyrazol-3-one derivatives;Diethylethoxymethylene malonate (DEEM);Substituted arylhydrazines;Michael addition reaction;Hypoglycemic activity
Issue Date: Oct-2008
Publisher: CSIR
Abstract: Several new aryl substituted pyrazol-3-one 3 derivatives were prepared by the reaction of substituted phenyl hydrazine 1 with diethylethoxymethylene malonate (DEEM) 2. The compounds were synthesized by Michael addition reaction, which is a nucleophilic addition of enolate anions to the carbon–carbon double bond of ⍺,β-unsaturated carboxylic acid derivatives. All the compounds were characterized by UV, IR and NMR spectroscopy and tested for hypoglycemic activity on alloxan induced diabetic rats. Among the tested compounds ethyl-2-para nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3c and ethyl-2-meta nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3d are identified as potent hypoglycemic agents and their activities are comparable with the standard drug metformin.
Page(s): 1555-1558
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(10) [October 2008]

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