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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(10) [October 2008] >
| Title: | Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents |
| Authors: | Das, Nirupam
Verma, Abhilasha
Shrivastava, Prabhat K
Shrivastava, Sushant K |
| Keywords: | Pyrazol-3-one derivatives
Diethylethoxymethylene malonate (DEEM)
Substituted arylhydrazines
Michael addition reaction
Hypoglycemic activity |
| Issue Date: | Oct-2008 |
| Publisher: | CSIR |
| Abstract: | Several new aryl substituted pyrazol-3-one 3 derivatives were prepared by the reaction of substituted phenyl hydrazine 1 with diethylethoxymethylene malonate (DEEM) 2. The compounds were synthesized by Michael addition reaction, which is a nucleophilic addition of enolate anions to the carbon–carbon double bond of ⍺,β-unsaturated carboxylic acid derivatives. All the compounds were characterized by UV, IR and NMR spectroscopy and tested for hypoglycemic activity on alloxan induced diabetic rats. Among the tested compounds ethyl-2-para nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3c and ethyl-2-meta nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3d are identified as potent hypoglycemic agents and their activities are comparable with the standard drug metformin. |
| Page(s): | 1555-1558 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(10) [October 2008]
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