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http://nopr.niscair.res.in/handle/123456789/2258
Title: | Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents |
Authors: | Das, Nirupam Verma, Abhilasha Shrivastava, Prabhat K Shrivastava, Sushant K |
Keywords: | Pyrazol-3-one derivatives;Diethylethoxymethylene malonate (DEEM);Substituted arylhydrazines;Michael addition reaction;Hypoglycemic activity |
Issue Date: | Oct-2008 |
Publisher: | CSIR |
Abstract: | Several new aryl substituted pyrazol-3-one 3 derivatives were prepared by the reaction of substituted phenyl hydrazine 1 with diethylethoxymethylene malonate (DEEM) 2. The compounds were synthesized by Michael addition reaction, which is a nucleophilic addition of enolate anions to the carbon–carbon double bond of ⍺,β-unsaturated carboxylic acid derivatives. All the compounds were characterized by UV, IR and NMR spectroscopy and tested for hypoglycemic activity on alloxan induced diabetic rats. Among the tested compounds ethyl-2-para nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3c and ethyl-2-meta nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3d are identified as potent hypoglycemic agents and their activities are comparable with the standard drug metformin. |
Page(s): | 1555-1558 |
URI: | http://hdl.handle.net/123456789/2258 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.47B(10) [October 2008] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 47B(10) 1555-1558.pdf | 70.78 kB | Adobe PDF | View/Open |
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