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http://nopr.niscair.res.in/handle/123456789/22575
Title: | A facile phase-transfer catalysed N-methylation of 2-substituted benzimidazoles |
Authors: | Dubey, P K Ramanatham, J Kumar, Ramesh Grossert, J S Hooper, D L |
Issue Date: | Nov-2000 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | N-Alkyl-2-acetylbenzimidazoles have been obtained by alkylating 2-acetylbenzimidazole in CH3CN at RT for 30 min in over 90% yield using triethylbenzylammonium chloride as phasetransfer catalyst and anhyd. K2CO3 as base. When the same conditions are used to methylate simple 2-alkylbenzimidazoles, poorer results were obtained. Optimum conditions have been worked out for the methylation of simple 2-alkylbenzimidazoles by changing (a) the solvent, (b) the phase-transfer catalyst, (c) the concentration of the phase-transfer catalyst and (d) the type of phase-transfer catalysis itself. Using the optimised conditions, a number of l-methyl-2-alkylbenzimidazoles have been synthesised in a facile manner. |
Page(s): | 867-871 |
URI: | http://hdl.handle.net/123456789/22575 |
ISSN: | 0975-0983(Online); 0376-4699(Print) |
Appears in Collections: | IJC-B Vol.39B(11) [November 2000] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 39B(11) 867-871.pdf | 408.17 kB | Adobe PDF | View/Open |
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