Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/22575
Title: A facile phase-transfer catalysed N-methylation of 2-substituted benzimidazoles
Authors: Dubey, P K
Ramanatham, J
Kumar, Ramesh
Grossert, J S
Hooper, D L
Issue Date: Nov-2000
Publisher: NISCAIR-CSIR, India
Abstract: N-Alkyl-2-acetylbenzimidazoles have been obtained by alkylating 2-acetylbenzimidazole in CH3CN at RT for 30 min in over 90% yield using triethylbenzylammonium chloride as phasetransfer catalyst and anhyd. K2CO3 as base. When the same conditions are used to methylate simple 2-alkylbenzimidazoles, poorer results were obtained. Optimum conditions have been worked out for the methylation of simple 2-alkylbenzimidazoles by changing (a) the solvent, (b) the phase-transfer catalyst, (c) the concentration of the phase-transfer catalyst and (d) the type of phase-transfer catalysis itself. Using the optimised conditions, a number of l-methyl-2-alkylbenzimidazoles have been synthesised in a facile manner.
Page(s): 867-871
URI: http://hdl.handle.net/123456789/22575
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.39B(11) [November 2000]

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