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IJC-B Vol.47B(10) [October 2008] >


Title: Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune
Authors: Kamat, Shrivallabh P
Menezes, Jose C
Siddhaye, Bhushan M
Paknikar, Shashikumar K
Issue Date: Oct-2008
Publisher: CSIR
Abstract: Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyanobacterium Nostoc commune having antibacterial activity. In the first route, methylative lactone ring opening of the coumarin 2 followed by catalytic hydrogenation of the cinnamyl double bond and subsequent PPA cyclization gives the methyl ether 5 of 1 which on demethylation gives 1 in excellent yield. Alternatively, catalytic hydrogenation of 2 followed by fusion with anhydrous AlCl₃ gives high yield of 1 in just two steps.
Page(s): 1597-1599
ISSN: 0376-4699
Source:IJC-B Vol.47B(10) [October 2008]

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