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Title: Synthesis of some new formazanyl-thiazolyl-indoles and formazanyl-oxazolyl-indoles as inflammation inhibitors
Authors: Bansal, Ekta
Srivastava, V K
Kumar, Ashok
Issue Date: May-2000
Publisher: NISCAIR-CSIR, India
Abstract: Various 3-(2-arylideneaminothiazol-4-yl)indoles 3a-e and 3-(2-arylideneaminooxazol-4-yl)indoles 3a'-e' on diazotisation with aniline afford 3-[2-(1'-phenyl-3′-substituted-aryl-formazan-4′-yl)thiazol-4-yl] indoles 4a-e and 3-[2-(1'-substituted-phenyl-3′-substituted aryl-formazan-4′-yl)oxazol-4-yl]indoles 4a' -e' respectively. All the compounds have shown interesting antiinflammatory activity in carrageenan induced oedema in rats at 50 mg/kg p.o. The most active compound in the series is 3-[2-(o-methoxybenzylidene) aminothiazol-4-yl] indole which has shown higher anti-inflammatory activity and lower ulcerogenic property than phenylbutazone.
Page(s): 357-362
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.39B(05) [May 2000]

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