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|Title:||Synthesis of some new formazanyl-thiazolyl-indoles and formazanyl-oxazolyl-indoles as inflammation inhibitors|
Srivastava, V K
|Abstract:||Various 3-(2-arylideneaminothiazol-4-yl)indoles 3a-e and 3-(2-arylideneaminooxazol-4-yl)indoles 3a'-e' on diazotisation with aniline afford 3-[2-(1'-phenyl-3′-substituted-aryl-formazan-4′-yl)thiazol-4-yl] indoles 4a-e and 3-[2-(1'-substituted-phenyl-3′-substituted aryl-formazan-4′-yl)oxazol-4-yl]indoles 4a' -e' respectively. All the compounds have shown interesting antiinflammatory activity in carrageenan induced oedema in rats at 50 mg/kg p.o. The most active compound in the series is 3-[2-(o-methoxybenzylidene) aminothiazol-4-yl] indole which has shown higher anti-inflammatory activity and lower ulcerogenic property than phenylbutazone.|
|Appears in Collections:||IJC-B Vol.39B(05) [May 2000]|
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