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Title: Synthesis and antimicrobial activity of 2-substituted-6-chloro-8-nitro-4-trichloromethyl-4H-1,3,2-benzodioxaphosphorin 2-oxides
Authors: Srinivasulu, D
Reddy, C Devendranath
Issue Date: Apr-2000
Publisher: NISCAIR-CSIR, India
Abstract: A series of 2-aryloxy/2-arylthio-6-chloro-8-nitro-4-trichloromethyl-4H-1,3,2-benzodioxaphosphorin 2-oxides 3 have been synthesized by-reacting 2-(2,2,,2-trichloro-1-hydroxyethyl)-4-chloro-6-nitrophenol 1 with different arylphosphorodichloridates 2 in the presence of triethylamine at 70-80°C. Some of these compounds are prepared by reacting the monochloride, 2-chloro- 6-chloro-8-nitro-4-trichloromethyl-4H-1, 3, 2-benzodioxaphosphorin 2-oxide 4, in situ with substituted phenol and thiols 5. The monochloride is prepared by condensing 2-(2,2,2-trichloro-1-hydroxyethyl)- 4-chloro-6-nitrophenol with phosphorus oxychloride. IR, 1H, 13C and 31P NMR and mass spectral data have been discussed. Some of these compounds have been screened for their antibacterial and antifungal activities.
Page(s): 317-320
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.39B(04) [April 2000]

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