Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/22455
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dc.contributor.authorSingh, Amarjit-
dc.contributor.authorPrasad, Ashok K-
dc.contributor.authorErrington, William-
dc.contributor.authorBelokon, Yuri N-
dc.contributor.authorKochetkov, Konstantine A-
dc.contributor.authorSaxena, Rajendra K-
dc.contributor.authorJain, Subhash C-
dc.contributor.authorParmar, Virinder S-
dc.date.accessioned2013-10-22T11:40:23Z-
dc.date.available2013-10-22T11:40:23Z-
dc.date.issued2000-01-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/22455-
dc.description10-15en_US
dc.description.abstractNine diethyl α-acetamido, α-alkylmalonates 3-11 (alkyl=methyl, benzyl, 3-fluorobenzyl, 4-fluorobenzyl, 2,6-difluorobenzyl, 3-trifluoromethylbenzyl, 4-trifluoromethylbenzyl, 2-chlorobenzyl and 3-chlorobenzyl) have been synthesised in three steps starting with diethyl malonate in overall yields of 49-90%. The structures of C-alkylated acetamidomalonates have been established on the basis of their spectral data, the structures of two compounds 9 and 11 are also confirmed on the basis of their X-ray crystallographic studies. Further, the X-ray crystal structure of the chiral monoethyl ester of α-acetamidomalonic acid 1 has been studied. None of our C-alkylated acetamidomalonate has been found to be a substrate for lipase-catalysed enantiodifferentiating deesterification/ hydrolysis of the symmetric diester groups.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.39B(01) [January 2000]en_US
dc.titleSynthetic and biotransformation studies on prochiral non-proteinogenic amino acids: Diethyl α-acetamido, α-alkylmalonatesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.39B(01) [January 2000]

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