Please use this identifier to cite or link to this item:
|Title:||A convenient synthesis of antiviral acyclic C-nucleosides incorporating 1,3,4-thiadiazine nucleus as a nucleobase|
|Authors:||Yadav, L D S|
|Abstract:||Adducts 4a-d obtained by nucleophilic addition of sulphenylated dimethyl sulphoxide derivatives 2a,b to glucose thiosemicarbazones 3a,b undergo intramolecular cyclisation, involving methanesulphinyl leaving group, with 90% H2SO4 and Pummerer rearrangement with glacial acetic acid to yield acyclic C-nucleosides, 2-arylamino-6-(5-aryl-1,3,4-thiadiazol-2-ylthio)-5-(-glucopentyl)-4H,5,6-dihydro-1,3,4-thiadiazines 6a-d and 2-arylamino-6-(5-aryl-1,3,4-thiadiazol-2-ylthio)-5- (-glucopentyl)-6-methylthio-4H,5,6-di hydro-1,3,4-thiadiazines 7a-d, respectively.|
|Appears in Collections:||IJC-B Vol.40B(08) [August 2001]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.