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Title: A convenient synthesis of antiviral acyclic C-nucleosides incorporating 1,3,4-thiadiazine nucleus as a nucleobase
Authors: Yadav, L D S
Singh, Smita
Dubey, Suman
Issue Date: Aug-2001
Publisher: NISCAIR-CSIR, India
Abstract: Adducts 4a-d obtained by nucleophilic addition of sulphenylated dimethyl sulphoxide derivatives 2a,b to glucose thiosemicarbazones 3a,b undergo intramolecular cyclisation, involving methanesulphinyl leaving group, with 90% H2SO4 and Pummerer rearrangement with glacial acetic acid to yield acyclic C-nucleosides, 2-arylamino-6-(5-aryl-1,3,4-thiadiazol-2-ylthio)-5-(-glucopentyl)-4H,5,6-dihydro-1,3,4-thiadiazines 6a-d and 2-arylamino-6-(5-aryl-1,3,4-thiadiazol-2-ylthio)-5- (-glucopentyl)-6-methylthio-4H,5,6-di hydro-1,3,4-thiadiazines 7a-d, respectively.
Page(s): 674-677
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(08) [August 2001]

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