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Title: Synthesis and antimicrobial activity of 2-substituted-2,3-dihydro- lH-naphtho[1, 8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides
Authors: Venugopal, M
Reddy, C Devendranath
Bavaji, M
Issue Date: Sep-2001
Publisher: NISCAIR-CSIR, India
Abstract: Several 2-alkylcarbamato/thiocarbamato/arylcarbamido/trichloromethyl/bis(2-chloro-ethyl)amino/chloroethoxy/aryloxy-2,3-dihydro-1H-naphtho-[1,8-de]-1,3,2-diazaphosphorine 2-oxides/sulfides (4 and 6) are synthesized by reacting equimolar quantities of 1,8-diamino-naphthalene 1 with various dichlorophosphinyl carbamates/thiocarbamates/arylcarbamides 3a-1, trichloromethylphosphonic dichloride 5a, bis(2-chloroethyl)phosphoramidic dichloride 5b, O-2-chloroethyl phosphoryl chloride 5c and arylphosphorothioic dichlorides 5d-e in the presence of triethylamine at 45-65°C. Their IR, 1H, 13C, 31P NMR and mass spectral data are discussed. All these compounds are found to have significant antifungal and antibacterial activity.
Page(s): 822-827
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(09) [September 2001]

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