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Title: Novel triheterocyclic systems by Mannich reaction on 3-arylsydnones : Synthesis of 3-aryl-4-[2'-(8′′-hydroxy-7"-quinolinylmethylamino)-thiazol-4'-yl]sydnones and 3-aryl-4-[2′-(3′′-acetyl-2"-hydroxybenzylamino)-thiazol-4'-yl] sydnones as possible antimicrobial agents
Authors: Mallur, Shanta G
Badami, Bharati V
Issue Date: Aug-2001
Publisher: NISCAIR-CSIR, India
Abstract: 3-Aryl-4 (2'-aminothiazol-4'-yl) sydnones 2a-m when subjected to Mannich reaction with 8-hydroxyquinoline give the triheterocyclic Mannich bases 3a-m. Similar reaction with orthohydroxy acetophenone resulted in the formation of the methylamino derivatives 4a-m. All these compounds have been evaluated for antimicrobial activity, while compounds 3a-m have been screened for their antitubercular activity also.
Page(s): 742-747
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(08) [August 2001]

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