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Title: An efficient synthesis of trans-γ-oxo-α,β-unsaturated carboxylic acids, the intermediates for patulolide A and pyrenophorin
Authors: Davis, K Joju
Bhalerao, U T
Rao, B Vittal
Issue Date: Aug-2001
Publisher: NISCAIR-CSIR, India
Abstract: An efficient synthesis of intermediates for macrolide antifungals patulolide A 14 and pyrenophorin 16 are described with the key steps involving (i) coupling of the alkyl lithium with α,β-unsaturated aldehyde 8. (ii) the oxidation of the cis-trans mixture of γ-oxo-α,β- unsaturated aldehyde to the trans-γ-oxo-α,β-unsaturated carboxylic acid 12.
Page(s): 656-661
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(08) [August 2001]

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