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|Title:||An efficient synthesis of trans-γ-oxo-α,β-unsaturated carboxylic acids, the intermediates for patulolide A and pyrenophorin†|
|Authors:||Davis, K Joju|
Bhalerao, U T
Rao, B Vittal
|Abstract:||An efficient synthesis of intermediates for macrolide antifungals patulolide A 14 and pyrenophorin 16 are described with the key steps involving (i) coupling of the alkyl lithium with α,β-unsaturated aldehyde 8. (ii) the oxidation of the cis-trans mixture of γ-oxo-α,β- unsaturated aldehyde to the trans-γ-oxo-α,β-unsaturated carboxylic acid 12.|
|Appears in Collections:||IJC-B Vol.40B(08) [August 2001]|
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