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Title: Synthesis and antimicrobial activiy of some bridgehead nitrogen heterocycles
Authors: Dhiman, A M
Wadodkar, K N
Patil, S D
Issue Date: Jul-2001
Publisher: NISCAIR-CSIR, India
Abstract: The reactions of 3-(3-aryl-1H-pyrazol-5-yl)-4-amino-5-mercapto-s-1,2,4-triazoles 2a-d with various reagents like monochloroacetic acid 3a-d, benzoin 4a-d, carbon disulphide 5a-d and phenacyl bromide 6a-d are described. The starting material, the 1,2,4-triazoles 2a-d have been prepared from 3-aryl pyrazol-5-carbohydrazides la-d. The products have been characterized on the basis of elemental analysis, IR and 1H NMR spectral data. All the newly synthesised compounds have been screened for antimicrobial activity against bacteria S. aureus, S. typhi, S. dysenteriae, P. vulgaris, P. mirabilis, B. subtilis and K. pneumoniae.
Page(s): 640-643
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(07) [July 2001]

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