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|Title:||Synthesis and antimicrobial study of heterocyclyl substituted s-triazoles,1,3,4-thiadiazoles, oxadiazoles and related heterocycles|
|Authors:||Dhiman, A M|
Wadodkar, K N
Patil, S D
|Abstract:||Cyclocondensation reaction of 1-(3-aryl-1H-5-pyrazol-5-yl)-4-substituted thiosemicarbazides 2a-d with 2N KOH solution yields s-triazoles 3a-h while with hot anhydrous ortho-phosphoric acid gives 2-(3-aryl-1H-pyrazol-5-yl)-5-amino-1,3,4-thiadiazoles 4a-h. Oxidative cyclisation of 2a-h with I2/KI in alkaline condition affords 1,3,4-oxadiazoles 5a-h. Some of the thiosemicarbazides 2a-d on reaction with CS2/DMF under reflux result in the formation of 5-(3-aryl-1H-pyrazol-5-yl)-2-mercapto-1,3,4-thia-diazoles 6a-h. Similarly, triazoles 3a-d with α-chloroacetic acid in the presence of fused sodium acetate yield thiazolo-s-triazolones 7a-d. The structures of these compounds have been established on the basis of their elemental analysis and spectral data and evaluated for their antimicrobial activity against gram-negative and gram-positive bacteria.|
|Appears in Collections:||IJC-B Vol.40B(07) [July 2001]|
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