Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/22363
Title: Synthesis and antimicrobial study of heterocyclyl substituted s-triazoles,1,3,4-thiadiazoles, oxadiazoles and related heterocycles
Authors: Dhiman, A M
Wadodkar, K N
Patil, S D
Issue Date: Jul-2001
Publisher: NISCAIR-CSIR, India
Abstract: Cyclocondensation reaction of 1-(3-aryl-1H-5-pyrazol-5-yl)-4-substituted thiosemicarbazides 2a-d with 2N KOH solution yields s-triazoles 3a-h while with hot anhydrous ortho-phosphoric acid gives 2-(3-aryl-1H-pyrazol-5-yl)-5-amino-1,3,4-thiadiazoles 4a-h. Oxidative cyclisation of 2a-h with I2/KI in alkaline condition affords 1,3,4-oxadiazoles 5a-h. Some of the thiosemicarbazides 2a-d on reaction with CS2/DMF under reflux result in the formation of 5-(3-aryl-1H-pyrazol-5-yl)-2-mercapto-1,3,4-thia-diazoles 6a-h. Similarly, triazoles 3a-d with α-chloroacetic acid in the presence of fused sodium acetate yield thiazolo-s-triazolones 7a-d. The structures of these compounds have been established on the basis of their elemental analysis and spectral data and evaluated for their antimicrobial activity against gram-negative and gram-positive bacteria.
Page(s): 636-639
URI: http://hdl.handle.net/123456789/22363
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(07) [July 2001]

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