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|Title:||Micelle catalysed methylene blue reduction by ascorbic acid: A procedure for the determination of Vitamin C in pharmaceutical samples|
|Abstract:||A new spectrophotometric method for ascorbic acid determination has been described. Methylene blue (MB) being a water-soluble, non- toxic, cationic dye (λmax 660 nm), has been observed to be immobilized successfully in the Stern layer of a cationic micelle (cetyl trime thyl ammonium bromide, CTAB) through hydrophobic interaction. The immobilized dye (λmax 660 nm) is quantitatively reduced by ascorbic acid (AA) in the alkaline medium (pH > 8.5). The progress of the reaction and stepwise bleaching of the blue colour of the dye gives a quantitative measure of ascorbic acid concentration. A single aliquot of the micelle stabilized MB could be used for the determination of ascorbic ac id in the range or 50-400ppm.|
|Appears in Collections:||IJC-B Vol.40B(07) [July 2001]|
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