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Title: Micelle catalysed methylene blue reduction by ascorbic acid: A procedure for the determination of Vitamin C in pharmaceutical samples
Authors: Mallick, Kaushik
Pal, Anjali
Pal, Tarasankar
Issue Date: Jul-2001
Publisher: NISCAIR-CSIR, India
Abstract: A new spectrophotometric method for ascorbic acid determination has been described. Methylene blue (MB) being a water-soluble, non- toxic, cationic dye (λmax 660 nm), has been observed to be immobilized successfully in the Stern layer of a cationic micelle (cetyl trime thyl ammonium bromide, CTAB) through hydrophobic interaction. The immobilized dye (λmax 660 nm) is quantitatively reduced by ascorbic acid (AA) in the alkaline medium (pH > 8.5). The progress of the reaction and stepwise bleaching of the blue colour of the dye gives a quantitative measure of ascorbic acid concentration. A single aliquot of the micelle stabilized MB could be used for the determination of ascorbic ac id in the range or 50-400ppm.
Page(s): 632-635
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(07) [July 2001]

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