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Title: Synthesis of 2, 3-diphenyl-5-methyl-6-aroylbenzo[1,2-b:5,4-b']difurans under PTC conditions and their anti-microbial activity
Authors: Reddy, Y Thirupathi
Reddy, P Narsimha
Rao, M Kanakalingeswara
Rajitha, Ms) B
Reddy, S M
Ms) Sridevi
Issue Date: Jun-2001
Publisher: NISCAIR-CSIR, India
Abstract: 2, 3-Diphenyl-6-hydroxybenzofuran 1 and 2, 3-diphenyl-5-acetyl-6-hydroxybenzofuran 3 have been synthesized under microwave irradiation. 2,3-Diphenyl-5-acetyl-6-aroylbenzo[1 ,2-b:5,4-b']difurans 5a-h and 6a-e have been synthesized from the reaction of 3 and phenacyl bromides 4a-h under PTC conditions using TBAHS4 (Tetrabutylammonium hydrogen sulphate) as a catalyst in good yields. The compounds 5a-h and 6a-e have been screened for antibacterial and antifungal activities. Compounds 5b and 5e have shown maximum inhibitory activity against E. coli and S. aureus, while compounds 5b, 5e-g and 6a show maximum spore germination inhibition against Fusarium moniforme.
Page(s): 479-483
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(06) [June 2001]

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