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Title: Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and biological activity evaluation of s-triazolo[3,4-b] [1,3,4]thiadiazoles,s-triazolo[3,4-b] [1,3,4]thiadiazines and s-triazolo [3',4':2,3] [1,3,4 ]thiadiazino[5,6-b]quinoxaline
Authors: Mohan, Jag
Issue Date: May-2001
Publisher: NISCAIR-CSIR, India
Abstract: The condensation of 3-p-(t-butylphenyl)-4-amino-5-mercapto-s-triazole 1, independently, with chloroacetic acid, α-haloketones, benzoin, 2,3-dichloroquinoxaline, aromatic carboxylic acids, carbon disulphide and aromatic carboxaldehydes furnishes in one step the cyclic products, 3-p-(t-butylphenyl)-7H-s-triazolo[3,4-b][1,3,4]thiadiazin-6(5H)-one 2, 6-aryl-3-p( t-butylphenyl)-7H-s-triazolo[3,4-b][1,3,4]thiadiazine 3, 3-p-(t-butylphenyl)-6,7-diphenyl-5H-s-triazolo[3,4-b][1,3,4] thiadiazine 4, 3-p-(t-butylphenyl)-5H-s-triazolo[3' ,4' :2,3][1,3,4] thiadiazino[5,6-b] quinoxaline 5, 3-p-(t-butylphenyl)-6-aryl-s-triazolo[3,4-b][1,3,4] thiadiazoles 6, 3-p-(t-butylphenyl)-s-triazolo[3,4-b][1,3,4]thiadiazole-6(5H)-thione 7 and 6-aryl-5,6-dihydro-3-p(t-butylphenyl)-s-triazolo[3,4-b] [1,3,4] thiadiazoles 8 respectively. The structures have been established on the basis of elemental analysis and spectral data. The antibacterial and antifungal activity of some of the compounds have also been evaluated.
Page(s): 368-371
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(05) [May 2001]

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