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Title: Thiazolidinyl-triazinoquinazolines as potent anti-inflammatory agents
Authors: Bansal, Ekta
Ram, Tilak
Sharma, Shalabh
Tyagi, Mirdula
Rani, Archana Preeti
Bajaj, Kiran
Tyagi, Ritu
Goel, Bhawna
Srivastava, V K
Guru, J N
Kumar, Ashok
Issue Date: Apr-2001
Publisher: NISCAIR-CSIR, India
Abstract: Some new 5-(5'-substituted-aryl-2'-oxo-4'-thiazolidin-1'-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino[2 ,3-c]quinazolines have been synthesized by [1,5]cyclocondensation of thiolactic acid with 5-arylidene hydrazino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino [2 ,3-c] quinazolines. All the compounds of the series have been screened for their anti-inflammatory activity. The most potent compound of the series 5-(5'-p-dimethylaminophenyl-2'-oxo-4'-thiazolidin-1'-yl) amino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino[2,3-c]quinazolines has shown 48.93% activity at a dose of 50 mg/kg p.o. The structures of the products have been delineated by chemical reactions, elemental analysis and spectral studies.
Page(s): 307-312
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.40B(04) [April 2001]

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